The Neem Enamelizer replaces toothpaste, and its application is for the brushing stage only. Keeping saliva alkaline is essential for healthy mineralized enamel. The Neem Enamelizer is an alkalinizing liquid-polish, made of organic and wild crafted ingredients of neem, cinnamon, coconut oil, olive oil, jojoba, soapwort and spring water. Only one tiny drop needed on a dry toothbrush. Avoid while pregnant.